| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to compounds of general formula (I) or to pharmaceutically acceptable salts thereof. In general formula (I), R 1 is lower alkyl, phenyl optionally substituted with one or more R 1' , cycloalkyl or pyridyl; each R 1' is independently a lower alkyl, halogen, -C(=O)NH 2 or cyano; R 2 is absent or is halogen, lower alkoxy, hydroxy or lower alkyl; R 3 is absent or is halogen, lower alkoxy, hydroxy or lower alkyl; R 4 is absent or is morpholinyl-lower alkylenyl; X is CH or N; and Y is CH or N. Compounds of formula (I) inhibit Btk (Bruton's tyrosine kinase). Compounds of formula (I) are useful for modulating the activity of Btk and treating diseases associated with excessive Btk activity. Compounds are useful in the treatment of cancer, autoimmune and inflammatory diseases caused by aberrant B-cell activation. (I). n EFFECT: invention also relates to pharmaceutical compositions containing compounds of formula (I) and at least one carrier, diluent or excipient. n 25 cl, 2 tbl, 20 ex |