http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2652125-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f96834e57d8e054e429b524c85d68c54 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-50 |
| filingDate | 2017-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6de83ac040f783438578728463289c68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87af89f99dbf31cdca3a71cc8f0db7be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f3b9b8bcf7d0a8f2d7239ccbede1796 |
| publicationDate | 2018-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2652125-C1 |
| titleOfInvention | Method of producing 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to organic chemistry, specifically to a method of producing 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, which includes condensation in the medium of phosphorus oxychloride of 2,6-dichloroaniline with 1-acetylimidazolidone-2, obtained by acetylation of ethylene urea with acetic anhydride. Acetylation is carried out at a temperature of 80–90 °C and holding for 3–4 hours, condensation is carried out for 3–4 hours at a temperature of 90–100 °C. After the condensation reaction, excess phosphorus oxychloride is distilled from the reaction mass, the residue is mixed with water and ice, the resulting aqueous solution is diacetylated or the reaction mass is mixed with water and ice, the resulting acidic solution is diacetylated. n EFFECT: novel, advanced and safer method is developed for use on an industrial scale, which simultaneously increases the yield and purity of the desired product – 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride, which is used in medicine to reduce blood pressure, intraocular pressure, heart rate, and has a sedative effect. n 1 cl, 2 ex |
| priorityDate | 2017-10-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 31.