http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2650641-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69ece09bafee7e0c49d1f7951a3faa2c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0455 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0459 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0463 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K101-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04 |
| filingDate | 2012-11-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04186d208f6c4106aeb3e97c89082b5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eff95599fd18e022a3b8d6f9de136256 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6ffe34819cc17a764594e1c1797d6753 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5c628e90c4df1cd04a5714bbf1aaecb |
| publicationDate | 2018-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2650641-C2 |
| titleOfInvention | Fluorine-18 and carbon-11 labeled radioligands for positron emission tomography (pet) imaging for lrrk2 |
| abstract | FIELD: medicine. n SUBSTANCE: group of inventions relates to the field of medicine, in particular to a method for visualizing positron emission tomography (PET) LRRK2 in an object tissue, according to which: a compound of formula I I where m is 0 or 1; X is -NH; R 1 is C 1-6 alkyl, C 3-6 cycloalkyl; R 2 is a halo-C 1-6 alkyl; R 3 is -OR 4 ; R 4 is C 1-6 alkyl; halo-C 1-6 alkyl; n is 0 or 1; R 5 and R 6 together with the nitrogen atom to which they are attached, form morpholine; and R 7 is a halo; or a pharmaceutically acceptable salt thereof, wherein the compound comprises at least one C 11 or F 18 label; allow the compound to penetrate into the tissue of the object and collect a PET image of the CNS tissue or brain. Also, a group of inventions refers to a method for visualizing PET LRRK2 in a CNS tissue or brain of an object, to compounds of formula I, to the use of compounds of formula I for the preparation of a diagnostic imaging composition LRRK2 and the use of the compounds of formula I for diagnostic imaging of LRRK2. n EFFECT: group of inventions provides an expansion of the arsenal of tools for the PET method. n 22 cl, 4 dwg, 3 ex, 2 tbl |
| priorityDate | 2011-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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