| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to an azaindole derivative of formula (1) or a salt thereof: (1), where R 1 is a cyclopentenyl group; a cyclohexenyl group; phenyl group; furanyl group which is optionally substituted with a group selected from the group consisting of a formyl group and C 1 -C 6 alkyl group (which is optionally substituted with a group selected from the group consisting of a hydroxy group and a di- or mono-(C 1 -C 6 alkyl)amino group); 1H-pyrazolyl group which is optionally substituted with a group, selected from the group consisting of C 1 -C 6 alkyl group and an oxetanyl group; thiazolyl group; oxazolyl group; an isoxazolyl group; 1,3,4-thiadiazolyl group; 1,2,4-oxadiazolyl group; 1,3,4-oxadiazolyl group which is optionally substituted with C 1 -C 6 alkyl group; pyridyl group which is optionally substituted with a group selected from the group consisting of a halogen atom, an amino group, a hydroxy group, an N-oxide group, C 1 -C 6 alkyl group (which is optionally substituted by a hydroxy group) and C 1 -C 6 alkoxy group (which is optionally substituted by a halogen atom); dihydropyranyl group; dihydrofuranyl group; or a 4,5-dihydro-1,3,4-oxadiazolyl group which is optionally substituted with a group selected from the group consisting of oxo and C 1 -C 6 alkyl group, R 2 represents a hydrogen atom; cyano group; (C 1 -C 6 alkoxy)carbonyl group; carbamoyl group; di- or mono-(C 1 -C 6 alkyl)carbamoyl group; C 1 -C 6 alkyl group which is optionally substituted with a group selected from the group consisting of a hydroxy group, C 1 -C 6 alkoxy groups, di- or mono-(C 1 -C 6 alkyl)amino group and a morpholinyl group; C 1 -C 6 alkoxy group; or a pyrazolyl group which is optionally substituted with C 1 -C 6 alkyl group, m is 0, n is 0 or 1, R 4 is C 2 -C 6 alkenyl group, and in the formula (I) the following structure: represents any of the following structures: . n EFFECT: compounds of the invention have a selective JAK3 inhibitory effect. n 9 cl, 9 tbl, 59 ex |