http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2646754-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bfefe61ebdf8cc1b47937964fd534441 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2013-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63c31770be851e01a3176798f1b6b201 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d02dd4cf70ec9a2952082981bd312347 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5200aa16ef5efcc7b0d72739a7a52b8a |
| publicationDate | 2018-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2646754-C2 |
| titleOfInvention | Pyrrolopyridinone derivatives as ttx-s blockers |
| abstract | FIELD: pharmaceutics. n SUBSTANCE: invention relates to a compound of the following formula (I): [Chem. 1] n , n wherein A is phenyl or 6-membered heteroaryl containing 1 to 2 heteroatoms of N; B is selected from the group consisting of -C 1-6 alkylene-NR 2 -, -NR 2 - and -(C=O)-; C is selected from the group consisting of -(C=O)- and -NR 2 -; R 1 is independently selected from the group consisting of: (2) -O n -C 1-6 alkyl wherein alkyl is unsubstituted or substituted by one or more substituents independently selected from R 11 , (3) -O n -C 3-7 cycloalkyl, where cycloalkyl is unsubstituted, (4) -O n -phenyl, wherein phenyl is unsubstituted or is substituted by one or more substituents independently selected from R 11 , (6) -S-phenyl, wherein phenyl is unsubstituted or is substituted by one or more substituents independently selected from R 11 ; (7) -NH-C 1-6 alkyl wherein alkyl is unsubstituted or substituted by one or more substituents independently selected from R 11 , and (9) -O n - (5-membered heteroaryl containing 1-2 heteroatoms selected from N), wherein heteroaryl is unsubstituted or substituted by one or more substituents independently selected from R 11 ; R 2 are independently selected from the group consisting of: (1) hydrogen, (2) halogen selected from chlorine, bromine and fluorine, (4) -O n -C 1-6 alkyl, (8) -O n -(6-membered heterocyclyl containing 1 N atom), wherein heterocyclyl is unsubstituted or is substituted by one or more substituents independently selected from R 7 , (9) -(C=O)-NR 8 R 9 and (10) -NR 8 R 9 ; R 3 and R 4 are independently hydrogen or C 1-6 alkyl; R 5 are independently selected from the group consisting of: (1) hydrogen and (3) -O n -C 1-6 alkyl; R 6 is independently hydrogen, C 1-6 alkyl, C 1-6 alkoxy, C 3-7 cycloalkyl, -NR 8 R 9 , 4-6 membered heterocyclyl containing 1-2 heteroatoms selected from N and O, phenyl, 5-6 membered heteroaryl containing 1-2 heteroatoms selected from N, O and S, phenyl-C 1-6 alkyl, (5-membered heteroaryl containing 2-3 heteroatoms selected from N) -C 1-6 alkyl or (6-membered heterocyclyl containing 1-2 heteroatoms selected from N and O) -C 1-6 alkyl, R 6 can form a 5-6-membered ring with R 2 . Values of other radicals are given in the patent claim. Invention also relates to compound of formula (II), compound of formula (III), pharmaceutical composition, condition or disorder treatment method, in which TTX-S channel blockers are involved, use of the compound, method for preparing a pharmaceutical composition, use of the composition. n EFFECT: new compounds of formula (I) have been obtained which have blocking activity with respect to potential-dependent sodium channels as TTX-S channels and which can be used in the treatment or prevention of disorders and diseases in which potential-dependent sodium channels are involved. n 15 cl, 4 tbl, 520 ex |
| priorityDate | 2012-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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