| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ce02804c597add535d0781d73ab2d2f1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-2207
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-01 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-468
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2881
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-445 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-52 |
| filingDate |
2013-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2018-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e125d11b76b5fa38018cc2243482e8dd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_473bc005a5b3d5e934e698175334cbf2 |
| publicationDate |
2018-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
RU-2646159-C2 |
| titleOfInvention |
Method for production and selection of molecules including, at least two different groups, and application thereof |
| abstract |
FIELD: biochemistry. n SUBSTANCE: invention relates to biochemistry. Proposed is a method of a multi-specific binding molecule preparation comprising at least two binding moieties, such as an antibody, where the method comprises culturing a cell containing a nucleic acid encoding soluble A sortase from S. aureus with a C-terminal retention signal in the endoplasmic reticulum, nucleic acid encoding a first binding group comprising a sortase motif at its C-end, followed by a retention signal in the endoplasmic reticulum, and a nucleic acid encoding a second binding group containing at least one diglycine at its N-end. Said cell secrets the sortase A mediated conjugate of the first binding group and the second binding group. n EFFECT: present invention provides an enzyme-catalyzed preparation of a multi-specific binding molecule and can find further application, in particular, for the rapid creation of such binding molecules’ libraries. n 7 cl, 4 dwg, 1 tbl, 3 ex |
| priorityDate |
2012-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |