| abstract |
FIELD: chemistry. n SUBSTANCE: present invention relates to compounds of formula (I), wherein residues R 1 -R 5 , V, G and M are as defined in the claims. Compounds by the present invention are effective platelet (GPR92) LPAR5 receptor antagonists, and they can generally be used in diseases, at which there is undesirable activation of LPA receptor LPAR5 platelets, LPA receptor LPAR5 mast cells or LPA receptor LPAR5 cells of microglia or for treatment or prevention of which inhibition of LPA receptor of platelet LPAR5, mast cells or microglial cells is expected. Moreover, present invention relates to methods for preparation of compounds of formula (I), their use, in particular as active ingredients in drugs, and to pharmaceutical compositions containing them. n . n EFFECT: compounds of formula (I) are valuable pharmacologically active compounds for use in the treatment of various diseases, such as cardiovascular disease, like thromboembolic disease or restenosis. n 9 cl, 3 tbl, 28 ex |