| abstract |
FIELD: pharmacology. n SUBSTANCE: invention relates to a compound of the formula n where R 1 represents a hydrogen atom, C 1-6 alkyl group, C 1-6 alkoxy group, di-C 1-6 alkylamino group; each of L 1 and L 2 independently represents a single bond, NR 2 , O, S or a C 1-6 alkylene group; B is a C 3-11 cycloalkylene group, a C 3-11 cycloalkenylene group, a 3 to 11-membered heterocyclylene group containing 1 to 5 heteroatoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom), a C 6-10 arylene group, a 5 to 10 membered heteroarylene group containing 1 to 5 hetero atoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom), a C 1-6 alkylene group or a C 2-6 alkenylene group; A is a C 1-6 alkyl group, a C 3-11 cycloalkyl group, a C 3-11 cycloalkenyl group, a 3 to 11-membered heterocyclyl group containing 1 to 5 heteroatoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom), a C 6-10 aryl group or a 5 to 10 membered heteroaryl group containing 1 to 5 heteroatoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom); L 3 is a C 1-6 alkylene group; D is a C 3-11 cycloalkyl group, a C 3-11 cycloalkenyl group, a 3 to 11-membered heterocyclyl group containing 1 to 5 heteroatoms as ring-forming atoms (the heteroatom is a nitrogen atom, an oxygen atom or a sulfur atom), a C 6-10 aryl group or a 5 to 10 membered heteroaryl group containing 1 to 5 heteroatoms as ring-forming atoms (the hetero atom is a nitrogen atom, an oxygen atom or a sulfur atom); the values of the remaining substituents are indicated in the claims. The invention also relates to a T-type calcium channel inhibitor, a prophylactic agent, a therapeutic agent for neuropathic pain, a medicament. n EFFECT: new compounds of the formula having inhibitory activity against T-type calcium channels are obtained. n 37 cl, 43 tbl, 876 ex |