| abstract |
FIELD: pharmacology. n SUBSTANCE: invention relates to a compound of the formula n and versions thereof that can be used as pharmaceutical agents, as well as pharmaceutical compositions containing such compounds that can be used to treat or prevent mucositis or infection. In the formula (I) m is 0, 1, 2 or 3; n is 0, 1, 2, or 3; o is 0, 1, 2, or 3; p is 0 or 1; r is 0 or 1; q is an integer from 1 to 400; Q x is NH, (C 1 -C 10 )alkyl, (C 2 -C 9 )heteroalkyl, (C 3 -C 10 )cycloalkyl, (C 2 -C 9 )heterocycloalkyl, (C 6 -C 14 )aryl, (C 2 -C 9 )heteroaryl; Q y is NH-R W , NH-CH 2 -R W , (C 1 -C 10 )alkyl or (C 6 -C 14 )aryl; R w is absent or is (C 1 -C 10 )alkyl, (C 2 -C 9 )heteroalkyl, (C 6 -C 14 )aryl or (C 2 -C 9 )heteroaryl; R x and R y , each independently represent a pharmaceutically acceptable end group. n EFFECT: invention allows to obtain a pharmaceutical composition having high antimicrobial activity and to use it in the treatment of mucositis of the oral mucosa, surgical wound infection and pulmonary infection associated with cystic fibrosis. n 90 cl, 1 dwg, 7 tbl, 57 ex |