http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2643104-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5205c25b782ff85e96fda9512faca381 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G09B23-28 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G09B23-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-021 |
| filingDate | 2017-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7416fe9556cc9180c5e47337d622914 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b26ffdd2f0d009e5b99cb768e2b474cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58967be4ca32659671b8bdb303f5da2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64f0fd6009308a88f28476eded3f8d48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_552fc031c7b252bd89c6e399f3a6ef39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_820e7d23e00d0cffa5cd866ece0e39c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_820f75e7b88da93277ea3cb9bb072ca3 |
| publicationDate | 2018-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2643104-C1 |
| titleOfInvention | Method of cardioprotective activity estimation of pharmacological facilities |
| abstract | FIELD: medicine; pharmacology. n SUBSTANCE: invention relates to medicine, namely, to experimental cardiac pharmacology, and can be used in a comprehensive assessment of the activity of pharmacological agents on an isolated rat heart. For this, method includes the registration of indices of contractility under conditions of imposing a high rhythm of contractions and hypercalcium load on the heart. At the same time, the parameters of the contractile function of the left ventricle are recorded, then a 20-minute perfusion of the heart with a solution containing 5 mmol/l of Ca 2+ is performed to determine the dynamics of the diastolic stress. In the future, the reduction frequency is set to 480 bpm for 15 seconds using an electric stimulator. Then the coefficient S TTI (area of defect diastole) is calculated in conventional units by folding trapezium squares under the curve of elevation of the end-diastolic pressure and evaluating the contractile function of the heart, taking into account the physiological values of S TTI . n EFFECT: method provides information and increase in the reliability of evaluation indicators of the degree of cardioprotective or cardiotoxic activity pharmacological means using the coefficient S TTI . n 1 cl, 2 dwg, 1 ex, 3 tbl |
| priorityDate | 2017-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.