http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2641003-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_29ebe9ae4e8e7d8a5064f16ab0ba1711 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-643 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C59-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4412 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 |
| filingDate | 2014-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc7b7e03f634c744a30c7a341f20e685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31bdef1c265c5d4a04efc042fb5e1534 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3441ece1e3febd91719b9483ecd33c6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39601b08c74a7d4af51b97d566ea415f |
| publicationDate | 2018-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2641003-C2 |
| titleOfInvention | Biaryl derivatives as agonists gpr120 |
| abstract | FIELD: pharmacology. n SUBSTANCE: invention relates to diaryl derivatives of the formula 1 , or their pharmaceutically acceptable salts or isomers of formula 1, wherein A and B are independently phenyl or pyridine provided that when B is phenyl, -G-COOR 7 is substituted in the para-position of phenyl and, when B is pyridine, -G-COOR 7 is substituted in position 3 of pyridine, any of R 1 -D and R 2 -E may be absent, D and E are independently carbon, nitrogen, oxygen or sulfur, or represent a direct bond, and any of R 1 and R 2 may be absent, or R 1 is a halogen, C 1 -C 6 -alkyl, optionally substituted with halogen, C 3 -C 10 -cycloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, C 3 -C 10 -heterocycloalkyl or C 1 -C 6 -alkyl-C 3 -C 10 -heterocycloalkyl, C 3 -C 10 -cycloalkyl, optionally substituted by C 3 -C 10 -alkylsilanyloxy or hydroxy, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 10 -heterocycloalkyl, optionally substituted by C 1 -C 6 -alkylamino or halogen, C 1 -C 6 -alkyl-C 3 -C 10 -heterocycloalkyl, phenyl, C 3 -C 9 -heteroaryl or C 1 -C 6 -alkyl-C 5 -C 6 -heteroaryl, R 2 is hydrogen, halogen, C 1 -C 6 -alkyl, optionally substituted with halogen, C 3 -C 10 -cycloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, C 3 -C 10 -heterocycloalkyl or C 1 -C 6 -alkyl-C 3 -C 10 -heterocycloalkyl, C 3 -C 10 -cycloalkyl, optionally substituted with C 3 -C 10 -alkylsilaniloxy or hydroxy, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, C 3 -C 10 -heterocycloalkyl, optionally substituted with C 1 -C 6 -alkylamino or halogen, C 1 -C 6 -alkyl-C 3 -C 10 -heterocycloalkyl, phenyl, C 3 -C 9 -heteroaryl or C 1 -C 6 -alkyl-C 5 -C 6 -heteroaryl and, when D and E represent nitrogen or carbon, R 1 and R 2 may represent two or three groups, which may be the same or different, isolated from C 1 -C 6 -alkyl or phenyl, G is -J-(CR 5 C 6 ) p , where J is oxygen or sulfur, R 5 and R 6 independently represent hydrogen, C 1 -C 6 -alkyl or C 3 -C 10 -cycloalkyl and R 5 and R 6 , substituted in the one and the same or different carbon atoms, may be bound producing C 3 -C 10 -cycloalkyl, R 1 and R 4 independently from each other may be absent depending on m and n value or independently represent hydrogen, halogen or C 1 -C 6 -alkyl, or C 1 -C 6 -alkoxy, R 7 is hydrogen or C 1 -C 6 -alkyl, m and n independently represent an integral number from 0 to 5 and p is an integral number from 2 to 6, where heterocycloalkyl and heteroaryl contain at least one heteroatom, isolated from N, O, and S, to the pharmaceutical composition, containing them, and method of its production. n EFFECT: stimulates the formation of GLP-1 in the gastrointestinal tract and improves insulin resistance in the liver or muscles, effective prevention or treatment of diabetes, complications of diabetes, obesity, non-alcoholic fatty hepatosis, steatohepatitis, osteoporosis or inflammation. n 6 cl, 1 tbl, 279 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2683648-C2 |
| priorityDate | 2013-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1612.