http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2639514-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aeabc7984b39c5ba6d2f080e0300c3a5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
| filingDate | 2016-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5cb849996daa25f56a4976053c0f5a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b8f7b642a6b8b12ba1cabf71ada9c05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06c05fe267fcfdef72fa474310474690 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47e2c47b6162df35b92a1679205ff184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fd51c9c35b76836ab1492e3f658c30d |
| publicationDate | 2017-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2639514-C1 |
| titleOfInvention | Method for obtaining antigen specific cytotoxic cells with anti-tumor cytotoxic activity against cells of non-small cells lung cancer |
| abstract | FIELD: biotechnology. n SUBSTANCE: invention is a method of generating Antigen-specific cytotoxic cells possessing antitumor cytotoxic activity against cells of non-small cell lung cancer, comprising obtaining dendritic cells from peripheral blood monocytes of a patient with non-small cell lung cancer, culturing dendritic cells in the presence of recombinant human granulocyte-macrophagic colony stimulating factor (rhGM-CSF) and interleukin-4 (rhIL-4), followed by tumor antigen loading and maturation with tumor necrosis factor (TNF-α) and interleukin-1β (IL-1β) for 24 hours, after which the mature dendritic cells are cultured in conjunction with the non-stick fraction of autologous mononuclear cells, where the co-cultivation of mature dendritic cells and non-stick fraction of autologous mononuclear cells is performed in the presence of 1-methyl-L-tryptophan (1 MT). n EFFECT: invention allows generating of in vitro T-cell clones with the activity of cytotoxic T-lymphocytes and T-helper type 1, necessary for the formation of an effective antitumor response against non-small cell lung cancer cells. n 1 tbl |
| priorityDate | 2016-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 146.