| abstract |
FIELD: pharmacology.SUBSTANCE: invention relates to a pharmaceutical composition comprising alisporivir in an amount of 15 to 20 wt % of the composition, water in an amount of 2 to 15 wt % of the composition, a carrier medium comprising a lipophilic component, a surfactant, a hydrophilic component containing ethanol. The composition preferably comprises polyethylene glycol or propylene glycol as the hydrophilic component, medium chain triglycerides or sorbitan monooleate as the lipophilic component, macrogolglycerin hydroxystearate, caprolocaproyl macrogol-8 glyceride or vitamin E polyethylene glycol succinate as the surfactant. The pharmaceutical composition of the invention is intended for oral administration in the form of a capsule.EFFECT: obtaining of an non-oversaturated composition of alisporivir with a high concentration.10 cl, 4 dwg, 12 tbl, 9 ex |