| abstract |
FIELD: esthetic medicine. n SUBSTANCE: group of inventions relates to a skin filler composition for treatment of wrinkles on the skin, containing hyaluronic acid cross-linked with a diamine crosslinker selected from lysine or a lysine methyl ester and a carbodiimide binder; to a method for preparation of the said composition, according to which cross-linking of hyaluronic acid with a diamine cross-linker selected from lysine or a lysine methyl ester is carried out in the presence of a carbodiimide binder; as well as a method of treatment of fine lines on the skin, comprising composition administration to the dermal region of a patient. n EFFECT: group of inventions provides an injectable skin filler composition that does not lead to blueing after introduction into the skin region of the patient, is not cytotoxic, has good mechanical properties and improved biocompatibility. n 11 cl, 18 ex, 6 tbl, 2 dwg |