| abstract |
FIELD: pharmacology. n SUBSTANCE: monoacetyl diacylglycerin according to the invention is a natural substance isolated from deer antlers. The monoacetyl diacylglycerols of the invention inhibit the expression of interleukin-4 (IL-4) in mouse T-cell lymphoma cells (EL-4), reduce airway hyperreactivity in experimental induced asthma in animals, and inhibit inflammatory cells penetration into the bronchial tree. In addition, the compounds of the invention reduce the immunoglobulin E (IgE) content in the blood serum and in the fluid obtained from bronchoalveolar lavage; have a pronounced effect of suppressing the expression of cytokines produced by Th2 cells (IL-4, IL-5 and IL-13) in the lungs, and have no side effects, are not toxic, and have an effective therapeutic effect. n EFFECT: asthma prevention or treatment. n 9 cl, 7 dwg, 7 tbl, 8 ex |