http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2636310-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10887e50e4a4825aab012ba9b621e097 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P5-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2015-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ca38f3b215482ea123cb3ee8055e791 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67f64f227af51cf535241af9d7cea55b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ed59f86fed496100ea51a61a0a04c09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e26c0efbad2787e02ef15eb10bba00e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c3fd9e0dfd5c1e4721a06dc04c49d6a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4efc9220db172223426cbe4167bcd117 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04dd7bca735534bacf6143a7956e1d74 |
| publicationDate | 2017-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2636310-C1 |
| titleOfInvention | New tetrahydropyrimidine connection or its salt |
| abstract | FIELD: pharmacology. n SUBSTANCE: invention relates to a new tetrahydropyridopyrimidine compound of the general formula (I) or a pharmaceutically acceptable salt thereof. The compounds possess an inhibitory activity against the androgen receptor (AR) and can be used to treat a tumour associated with activity (AR). In the general formula n , n X is a halogen atom or halogen-C 1-3 an alkyl group; R is a phenyl group which is substituted by R 1 and can also be substituted by R 2 , or a 5- or 6-membered heteroaryl group which contains 1 to 3 heteroatoms selected from a nitrogen, oxygen or sulfur atom and which is substituted by R 1 and can also be substituted by R 2 ; R 1 represents a hydrogen atom, a phenyl group, a hydroxy-C 1-6 alkyl group, hydroxy-C 3-7 cycloalkyl group,C 1-6 an alkoxy group which may be substituted by Ra, C 3-7 a cycloalkylaminosulfonyl group, a (6-7) membered monocyclic heterocycloalkylsulfonyl group, with two nitrogen atoms or a nitrogen atom and an oxygen atom in the ring; halogen-C 1-3 alkoxycarbonylamino group, halogen-C 1-3 alkylcarbonylamino group, a (5-7)membered monocyclic heterocycloalkanecarbonyl group,containing a nitrogen atom in the ring, and substituted with hydroxy-C 1-6 alkyl group, or - (CH 2 ) n -C(=O)-NHRf; R 2 is a hydrogen atom, a halogen atom or a halogen-C 1-3 an alkyl group; Ra is C 1-6 alkylpyrazolyl group, a triazolyl group, a tetrazolyl group or a C 1-6 alkylsulfonylpiperazinyl group; Rf is halogen-C 1-3 alkyl group, hydroxy-C 1-6 alkyl group, hydroxy-C 3-7 cycloalkyl group, hydroxy-C 3-7 cycloalkyl-C 1-6 alkyl group C 1-6 alkyl group, substituted by Rfa; Rfa is C a 1-6 alkylpyrazolyl group, halogen-C 1-3 alkylthiazolyl group, an oxadiazolyl group or a halogen-C 1-3 alkyloxadiazolyl group; and n is an integer from 0 to 3. n EFFECT: obtaining of a new compound. n 20 cl, 5 tbl, 63 ex |
| priorityDate | 2014-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 624.