http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2632203-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a0ab78dd7508a7648f7be50be6002433 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-803 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-803 |
| filingDate | 2013-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_672a9322c60b02b6830d578213cc16a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e52f1f4df90eaa4359b78a325fb78383 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ba55bc29dd12fcb408efb697c4fbeab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a652ce7790b7a5d00d884116d5ef3daf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cabf883c079c1107c35a35015f82a4c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d2d7f8522b39b7dac7c56896b1b2d4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3b2c715b77831798615b732b8dc7792 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d532756bbad64467efb41ea11aa735a5 |
| publicationDate | 2017-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2632203-C2 |
| titleOfInvention | Method for producing 4-amino-5-fluoro-3-halogen-6- (substituted) pycolinates |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to the method for producing a compound of the formula (I): n n n n or salt thereof, wherein W is Cl, Br or I; R is phenyl substituted with 0-5 substituents independently selected from halogen and C 1 -C 4 -alkoxy, and R 1 is C1-C 12 -alkyl or unsubstituted or substituted C 7 -C 11 -arylalkyl; comprising: (a) fluorinating a compound of the formula (II): n n n n where A 6 is halogen or R, a source of a fluoride ion to produce a compound of the formula (III): n n n n where B 6 is F or R; and converting a compound of the formula (III) to a compound of the formula (IV): n n n n (b) halogenating a compound of the formula (IV) with a halogen source to produce a compound of the formula (V): n n n n (c) condensing a compound of the formula (VI): n n n n where X is Cl, Br or I; A 2 is hydrogen or R 1 ; A 3 represents hydrogen or W; A 4 is Cl, F, NH 2 , NHCOCH 3 , or a protected amino group; A 5 is F or Cl; with a compound of the formula (VII): n , n where Met is Zn-halide, Zn-R, tri (C 1 -C 4 alkyl) tin, copper or B (OR 2 ) (OR 3 ), where R 2 and R 3 each independently is hydrogen, C 1 -C 4 alkyl or taken together form an ethylene or propylene group; in the presence of a catalyst based on transition metal to produce a compound the of the formula (VIII): n n n n where conversion (c) can be carried out before, between, or after transformations (a) and (b). n EFFECT: increased quality of output. n 17 cl, 29 ex |
| priorityDate | 2012-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 438.