http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2631856-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_edb5c4769f0680f728373b2f678e2846 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-10 |
| filingDate | 2016-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5abef6c53ce0a0779988702dbc97fdb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06569729f56bda4eae8c770cd60f67c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a5a50e98b9fef714cac2a616d410f72 |
| publicationDate | 2017-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2631856-C1 |
| titleOfInvention | Method for preparing ammonium salts of 3-amino-8-hydroxy-1,6-dioxo-4-cyano-2,7-diaaspiro [4,4] non-3-en-2-ids |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to the preparation of ammonium salts of functionally substituted diazaspyrans, specifically 3-amino-8-hydroxy-1,6-dioxo-4-cyano-2,7-diazaspiro [4,4] non-3-ene-2-ids of the formula 1 , where R 1 =R 2 =CH 3 , R 3 =H, R 4 +R 5 =(C 2 H 4 ) 2 O; R 1 =CH 3 , R 2 =C 2 H 5 , R 3 =H, R 4 =R 5 =C 2 H 5 ; R 1 =CH 3 , R 2 =C 3 H 7 , R 3 =H, R 4 +R 5 =(C 2 H 4 ) 2 O; R 1 =CH 3 , R 2 =C 3 H 7 , R 3 =H, R 4 =R 5 =C 2 H 5 ; R 1 =CH 3 , R 2 =C 3 H 7 , R 3 =R 4 =H, R 5 =t-Bu; R 1 =R 2 =R 3 =CH 3 , R 4 =R 5 =C 2 H 5 ; R 1 +R 2 =(CH 2 ) 4 , R 3 =CH 3 , R 4 +R 5 =(C 2 H 4 ) 2 O; R 1 +R 2 =(CH 2 ) 4 , R 3 =CH 3 , R 4 =H, R 5 =CH 2 Ph; R 1 =Ph, R 2 =R 4 =R 5 =CH 3 , R 3 =H; R 1 =Ph, R 2 =CH 3 , R 3 =H, R 4 =R 5 =C 2 H 5 ; R 1 =Ph, R 2 =CH 3 , R 3 =R 4 =H, R 5 =t-Bu. The method consists in adding an appropriate amine HNR4R5 to the suspension of the corresponding 3-amino-8-hydroxy-1,6-dioxo-2,7-diazaspiro [4,4] non-3-ene-4-carbonitrile in an organic solvent and stirring for 3-24 hours at room temperature, after which the precipitate is filtered off, washed with propan-2-ol. Ammonium salts of functionally substituted diazaspyranes may find use as inhibitors of integrase of HIV-1, tyrosine kinase, telomerase, inhibitors or agonists of 5-hydroxytryptamine receptors, endothelin receptor antagonists, agents that have the effect of inducing apoptosis of blast cells (BALL-1). n EFFECT: simplifying the process and increasing the yield. n 11 ex |
| priorityDate | 2016-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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