| abstract |
FIELD: pharmacology. n SUBSTANCE: invention relates to compounds of formula (Ie) or pharmaceutically acceptable salts thereof: where Z is NR 7 R 8 or S(O)aR 7 , where a is 0; R 1 is H or C 1 -C 6 alkyl optionally substituted with one or more substituents selected from hydroxyl, C 1 -C 6 alkoxy; Each of R 2 and R 4 is independently -Q 1 -T 1 , wherein Q 1 is a bond or a C 1 -C 3 alkyl linker optionally substituted with one or more substituents selected from halogen and hydroxyl, and T 1 is H, C 1 -C 3 alkyl; R 3 is H or halogen; R 5 is H or C 1 -C 6 alkyl; R 6 is H, halogen, -C(O)NR a R b or R S2 , where R S2 is C 1 -C 6 alkyl or 4-12 membered heterocycloalkyl containing from 0 to 3 heteroatoms in the ring selected from O, N or S, and Wherein each of R a and R b is independently H, C 1 -C 6 alkyl or R a and R b together with the N atom to which they are attached form a 4-12 membered heterocycloalkyl ring containing 0 or 1 additional heteroatom selected from O, N or S; R 7 is -Q 4 -T 4 , wherein Q 4 is a bond or a C 1 -C 4 alkyl linker and T 4 is H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, C(O)-C1-C 6 alkyl or 4-14 membered heterocycloalkyl, Containing 1 to 3 ring heteroatoms selected from O, N or S, each of which is optionally substituted with one or more -Q 5 -T 5 , wherein Q 5 is a bond, C(O), C(O) NR k , NR k C(O) or a C 1 -C 3 alkyl linker, wherein R k is H or C 1 -C 6 alkyl, and T 5 is H, C 1 -C 6 alkyl; R 8 is H, C 1 -C 6 alkyl optionally substituted with halogen or C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl or 4- to 7-membered heterocycloalkyl containing 1-3 heteroatoms in the ring selected from O, N or S; or R 7 and R 8 together with the N atom to which they are attached form a 4-12 membered heterocycloalkyl ring containing 0-2 additional heteroatoms selected from O, S or N and a 4-12 membered heterocycloalkyl ring that forms R 7 and R 8 is optionally substituted with one or more -Q 6 -T 6 , wherein Q 6 is a bond or a C 1 -C 3 alkyl linker and T 6 is H, halogen, C 1 -C 6 alkyl; and R 12 is halogen, C 1 -C 6 alkoxyl, C 2 -C 6 alkenyl or C 1 -C 6 alkyl optionally substituted with halogen. n EFFECT: compounds are used to treat cancer. n 24 cl, 4 tbl, 47 ex |