| abstract |
FIELD: biotechnology. n SUBSTANCE: binding molecule specifically binding to two different epitopes on HER2 and a method for its preparation, as well as a nucleic acid encoding it, expressing a vector comprising this nucleic acid molecule, a host cell for expression of a binding molecule transformed with the expression vector, and a pharmaceutical composition for cancer treatment comprising a binding molecule or a nucleic acid molecule encoding it, or an expression vector, are proposed. The proposed binding molecule comprises the first polypeptide comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:1, and the second heavy and light chain antibody polypeptide comprising amino acid sequences at least 95% identical to SEQ ID NO:NO:154 and SEQ ID NO:155, respectively. The presented group of inventions is applicable in medicine for anti-tumour therapy. n EFFECT: binding molecule effectively suppresses the tumour cells growth and shows high antiproliferative activity. n 17 cl, 13 dwg, 1 tbl, 14 ex |