| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to compounds of formula (I): , wherein the residues R 1 , R 1 ' and R 1 สบ independently represent hydrogen, alkoxy, halogen or -CF 3 group. The residue R 2 it represents C 1-7 alkyl or phenyl, or a pharmaceutically acceptable salt thereof. Also pharmaceutical composition, using the compounds of formula I, and method of treatment are provided. n EFFECT: compounds of formula I are inhibitors immunoproteasomal subunit LMP7, and may be useful in the treatment of inflammatory diseases and disorders such as rheumatoid arthritis, lupus and irritable bowel syndrome. n 13 cl, 1 tbl, 5 ex |