| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: group of inventions relates to field of chemical-pharmaceutical industry, namely to pharmaceutical composition in form of tableted form with delayed release, which contains 30-40 wt % of clozapine as active component and additional substances: 20-35 wt % of Methocel K100 LV, 10-15 wt % of Methocel K4M, 12-30 wt % of microcrystalline cellulose, 2-3 wt % of copovidone, 0.5-1 wt % of colloidal silicon dioxide and 0.5-1 wt % of pharmaceutically acceptable salt of stearic acid, as well as to method of obtaining said pharmaceutical composition. n EFFECT: group of the inventions provides obtaining clozapine tablets, possessing stability and reproducible kinetics of delayed release of active substance. n 8 cl, 4 ex, 4 tbl, 3 dwg |