http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2621636-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcf4c167203f3bda457d6e9e0526789d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-53 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate | 2016-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d9324155e9192d7d0c3537f1001b3e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20b5d2132965eeaeec5f91a760ce5799 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32fc82a492beca96e00789389492bb66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_749eb2330a8004a6656a94826f7dd07d |
| publicationDate | 2017-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2621636-C1 |
| titleOfInvention | Method for vulvovaginal candidiasis recurrence prediction |
| abstract | FIELD: medicine. n SUBSTANCE: invention relates to a method for recurrent vulvovaginal candidiasis (VVC) prediction. The essence of the method: the patient is genotyped according to polymorphic genes loci IL4:-33 C>T [rs2070874]; CCL2:2493(-2578) A>G [rs1024611]; IL1B:-598(-1552) A>G [rs16944] using real-time PCR, and the lactobacilli fraction in the vaginal microflora is determined using the "Femoflor 16" reagent kit, after which the obtained data are included in the function Z=1.063*IL1B+1.112*IL4+1.483*CCL2-0.044*Lact+1.326, where 1.326 is a constant, IL1B is the number of G alleles of in the IL1B:-598(-1552) A>G [rs16944] locus of the IL1B gene, IL4 is the number of C alleles in the IL4:-33 C>T [rs2070874] locus of the IL4 gene, CCL2 is the number of G alleles in the CL2:2493(-2578) A>G [rs1024611] locus of the CCL2 gene, Lact is the percentage of lactobacilli (%) in the vaginal microflora. The probability of recurrent VVC is determined by the formula p=1/(1+e -z ), if the value of p is greater than 0.5, then there is reason to expect the development of recurring VVC, and if the value of p is less than 0.5, then the development of recurring VVC is unlikely. n EFFECT: invention characterizes a low-invasive method and is an affordable test to improving the management of patients with vulvovaginal candidiasis. n 2 ex, 2 tbl |
| priorityDate | 2016-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 91.