http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2619465-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9b09e6758bbafab5fcafd92f7cec6fe1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2013-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1c8f6e1b8cc650ce783465609537ef0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a474477a76f38c46c5fc2d34b05da4a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_545ce570a24d07b2b2d5157aed37341d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc4647b90d825e748951ee737a9e2f42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f25fb03ef4d27ba76921a7b70453901a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba72c28939a67ecfa18026b425254c19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33f425d2053c60bae5a5e01370c59b75 |
| publicationDate | 2017-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2619465-C2 |
| titleOfInvention | Bruton's tyrosine kinase inhibitors |
| abstract | FIELD: pharmacology. n SUBSTANCE: compounds can be used as therapeutically active substances for the treatment of inflammatory and/or autoimmune conditions selected from rheumatoid arthritis and asthma. In formula I n n n n A is phenyl, n is 1 or 2, R 1 is CH 2 NHC(=O)R 1' or CH 2 NHC(=O)CH 2 NHR 1' , where n is 1. And one R 1 is halogen, and the other R 1 represents CH 2 NHC(=O)R 1' or CH 2 N(CH 3 )C(=O)R 1' , when n is 2. R 1' represents a lower alkoxy group, phenyl, an unsaturated or partially unsaturated 8-9-membered bicyclic heterocycle containing 1-2 heteroatoms in the bicyclic system selected from nitrogen and sulfur, or a 4-6-membered monocyclic heteroaryl with 1-3 heteroatoms selected from nitrogen, oxygen and sulfur, or a 4-5-membered heterocycloalkyl containing oxygen or nitrogen atoms as heteroatoms, optionally substituted by one or more R 1" . Each radical R 1" is an independent lower alkyl, halogen, 3-6-membered cycloalkyl, 4-membered heterocycloalkyl with an oxygen atom as a heteroatom, lower alkyl-4-membered heterocycloalkyl with an oxygen atom as a heteroatom, oxo group, cyano-lower alkyl, hydroxyl-lower alkyl or lower alkoxy group. R 2 is H, R 3 or R 4 . R 3 represents C(=O)OR 3' , C(=O)R 3' or C(=O)NH(CH 2 ) 2 R 3' . R 3' is H, a lower alkyl, 6-membered heterocycloalkyl with 1-2 heteroatoms selected from nitrogen and oxygen, an amino group or OH. R 4' is a pyrasolyl possibly substituted with R 4' . And R 4' is a methyl, CH 2 -CH 2 N(CH 3 ) 2 , CH 2 C(=O)OCH 2 CH 3 , CH 2 C(=O)OH or CH 2 CH 2 OH. n EFFECT: increased efficiency of treatment. n 18 cl, 2 tbl, 51 ex |
| priorityDate | 2012-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 548.