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publicationDate 2017-05-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2619216-C1
titleOfInvention Method of selecting the immunosuppression regime to children of early age in a remote period after transplantation of the liver
abstract FIELD: medicine. n SUBSTANCE: one year after transplantation in blood serum, the content of insulin-like growth factor 1 (IGF-1) and soluble CD30 (sCD30) is determined in liver recipients, and the dose of tacrolimus is adjusted to the specific concentration of IGF-1 and sCD30, the daily dose of tacrolimus is determined by formula D=1.3764+0.0081×G-0.0026×C, where D is the daily dose of tacrolimus, mg; G - serum level of IGF-1, ng/ml; C - content of sCD30 in serum, ng/ml. n EFFECT: use of this method allows for effective prevention of complications in young children after liver transplantation for congenital diseases of the hepatobiliary system in the long-term due to individual selection of tacrolimus concentration one year after liver transplantation. n 5 ex
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