| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a compound of formulas Ia n n n n and Ib n , n in any of its stereoisomeric form or its physiologically acceptable salt, where G R 71 -O-C(O)-; R1 represents hydrogen; R2 represents hydrogen; R 10 represents R 11 ; R 11 represents Ar; R 30 is selected from the group including a (C 3 -C 7 )-cycloalkyl and R 32 -C u H 2u -, where u means an integer chosen from the series containing 0, 1, 2 and 3; R 32 represents a phenyl, optionally substituted by one or more identical or different substituents selected from the group comprising a halogen, a (C 1 -C 6 )-alkyl, R 33 and (C 1 -C 6)- alkyl-O-; R 33 is a phenyl optionally substituted by one substitute selected from a halogen; R 40 is selected from the group consisting of hydrogen and (C 1 -C 4 )-alkyl, or R 30 and R 40 together represent (CH 2 ) x , where x is an integer selected from the group comprising 2, 3, 4 and 5; R 50 is hydrogen; R 60 is hydrogen; R 71 is hydrogen; Ar, independently of each other Ar group, is selected from the group comprisng a phenyl and an aromatic 5-membered or 6-membered monocyclic heterocycle containing one or two heteroatoms selected from nitrogen and attached via a ring carbon atom, where the phenyl and the heterocycle all are optionally substituted by one or more identical or different substituents selected from the group comprising a halogen, a (C 1 -C 6 )-alkyl, (C 1 -C 6 ) alkyl-O- and CF 3 ; where all the alkyl substituents, independently from each other and independently of any other substituents, are optionally substituted by one or more fluorine atoms. The invention also relates to obtaining the compound of formulas Ia and Ib, or a physiologically acceptable salt thereof, that is prepared by reacting a compound of formula IIa or IIb with the compound. The compound of formulas Ia and Ib or its physiologically acceptable salt is intended for use as a pharmaceutical agent having the inhibitory activity against cathepsin A. n EFFECT: substituted derivatives of the 3-thiazoleaminepropionic acid as protease inhibitors of cathepsin A. n 7 cl, 1 tbl |