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filingDate 2016-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2017-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_99144a7d669a1d29ddc334909bc916bb
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publicationDate 2017-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2616533-C1
titleOfInvention Method for everolimus therapy efficiency prediction for patients with metastatic renal cancer
abstract FIELD: medicine. n SUBSTANCE: phospho-m-TOR is determined, and HIF-1 hypoxia induced factor,α VEGF vascular endothelial growth factor and its VEGFR2 receptor are determined additionally at the pre-operative treatment stage. At HIF-1α, VEGF, VEGFR2 values in the well of 16.2 AU/mg of protein in the well; 100.5 and 82.2 pg/mg of protein, respectively, as well as phospho-m-TOR levle less than 5.5 pg/mg of protein, high efficiency of everolimus therapy is predicted. At HIF-1α, VEGF, VEGFR2 values less than 16.2 AU/mg of protein in the well, 100.5 and 82.2 pg/mg of protein, respectively, and phospho-m-TOR level more than 5.5 pg/mg of protein, low efficiency of everolimus therapy is predicted. n EFFECT: method provides high accuracy of everolimus therapy efficiency prediction, which, in turn, allows to select the appropriate therapy. n 3 ex
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