http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2613579-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d1db4fd39995c67e35c4db305de2585 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4188 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4188 |
| filingDate | 2012-04-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c98246a9e8aecba8c69bfcaaa34bc2f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b76f27b63869f175381127092f90f58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a67880beee018756efc777682d1d20b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cdef8e3a48827ed4361afe9dd419f380 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb6d8aba20a83c0c5433ed81d518dc49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4971674dc50d7d771fd21d775e8567ce |
| publicationDate | 2017-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2613579-C2 |
| titleOfInvention | Ido inhibitors |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to organic chemistry, in particular, to derivatives of imidazo[5,1-a]isoindole of structure given below, or to a stereoisomer or pharmaceutically acceptable salt thereof, where bond α is a single or double bond; n = 0 or 1; R 1 : halogen or -OR; R 2 : -C 1-4 alkyl-R A or -C 2-4 alkenyl-R 3 , if bond α is a single bond; and R 2 : =C(H)R A , if bond α is a double bond; in which R A : -CN, -C(O)R 3 , -C(O)OR 3 , -C(O)N(R 3 )(R C ), -C(OR B )(R 3 )(R C ), -C(NHR B )(R 3 )(R C ), or -C(=N-OR C )R 3 , where R B : hydrogen, -C(O)R 3 , -C(O)N(H)R 3 , -C(O)(CH 2 ) 2 COOR, -C(O)(CH 2 ) 1-4 (NR)COOR, -C(O)CH(NH 2 )(R D ), or -P(O)(OR 3 ) 2 ; where R D : methyl or -CH(CH 3 ) 2 ; R 3 : hydrogen, C 1-6 alkyl, phenyl, imidazolyl, furanyl, thiazolyl, pyridinyl, C 5-6 cycloalkyl, C 3-8 cycloalkenyl, piperidinyl, pyrrolidinyl, tetrahydropyranyl, azetidinyl or C 6 cycloalkylC 1 alkyl-, where each alkyl, cycloalkyl, piperidinyl, pyrrolidinyl, tetrahydropyranyl and azetidinyl is optionally and independently substituted with one group =R 32 and optionally and independently substituted with one or two groups R 31 ; each phenyl, imidazolyl, furanyl, thiazolyl and pyridinyl is optionally substituted with one or two groups R 31 ; where R 31 : halogen, nitro, C 1-6 alkyl, -C 1-6 alkyl-R 33 , C 1-6 haloalkyl, -OR, -N(R) 2 , -C(O)OR, -C(O)N(R) 2 , -C(O)R, -S(O) 2 R, -OC(O)R, -N(R)C(O)R or -N(R)C(O)OR, where R 33 : -OR; R 32 : =O, =C(R 34 ) 2 , =(spiro-C 3-8 cycloalkyl), or =(spirodioxalanyl), where R 34 : hydrogen, halogen, C 1-6 alkyl or -C 1 alkyl-OR; R C : hydrogen or C 1-6 alkyl; and R: hydrogen or R 10 , where R 10 : C 1-6 alkyl, phenyl, thiophenyl, C 5-6 cycloalkyl, pyrrolidinyl, tetrahydropyranyl, phenylC 1-6 alkyl, heteroarylC 1-2 alkyl- (where heteroaryl group is a pyridine, pyrimidine or imidazole) or tetrahydropyranC 1 alkyl, where each of alkyl, phenyl, cycloalkyl and phenylC 1-2 alkyl optionally substituted with one or two groups, which independently represent a halogen, C 1-6 alkyl, C 1 haloalkyl, -OR 11 , -N(R 11 ) 2 or -N(R 11 )S(O) 2 R 11 , where R 11 : hydrogen or C 1-6 alkyl. Invention also relates to specific compounds, pharmaceutical composition based on declared imidazo[5,1-a]isoindole and a method of treating indoleamine-2,3-dioxygenase (IDO) mediated immunosuppression. n EFFECT: novel derivatives of imidazo[5,1-a]isoindole are obtained, having useful biological properties. n 42 cl, 1 dwg, 75 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2786586-C2 |
| priorityDate | 2011-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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