| abstract |
FIELD: pharmaceutics. n SUBSTANCE: present group of inventions relates to verbenol derivatives, pharmaceutical composition for preventing or treating degenerative cerebral disease, selected from stroke, paralysis, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis, which contains verbenol derivative as active substance, as well as food additive with effect of protection of neurons, suppression of oxidative stress, suppression of cytokines expression, including verbenol derivative, wherein said verbenol derivative is selected from group, consisting of: (1S,5R)-4-(4-hydroxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one; (1S,5R)-4-(3,4-hydroxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one; (1S,5R)-4-(3,4-dihydroxy-5-methoxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one; (1S,5R)-4-(2-hydroxy-4-methoxystyryl)-6,6-dimethylbicyclo[3.1.1]hept-3-en-2-one; (1S,5R)-6,6-dimethyl-4-((E)-2-(pyridin-2-yl)vinyl)-bicyclo[3.1.1]hept-3-en-2-one; and their pharmaceutically acceptable salts. n EFFECT: prevention and treatment of cerebral diseases. n 7 cl, 10 dwg, 2 tbl, 2 ex |