| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to organic chemistry, specifically to 2-(azaindol-2-yl)benzimidazole derivatives of formula (I) or a pharmaceutically acceptable salt thereof, where R 1 is hydrogen; R 2 is hydrogen, perhalomethylC 0-5 alkyl-O- or C 1-6 alkoxy; R 3 is C 1-6 alkyl or C 1-6 alkoxyC 1-6 alkyl; R4 is C 1-6 alkyl, perhalomethylC 1-6 alkyl or unsubstituted C 3 cycloalkylC 1-6 alkyl; A is C-R 5 or N; B is C-R 6 or N; D is C-R 7 or N; provided that one of A, B and D is N; R 5 , R 6 and R 8 are hydrogen; R 7 is hydrogen, C 1-6 alkoxy or hydroxy; R 9 is hydrogen or hydroxy; R 10 is hydrogen or C 1-6 alkyl. Invention also relates to specific derivatives of 2-(azaindol-2-yl)benzimidazole and a pharmaceutical composition based on compound of formula (I). n EFFECT: novel derivatives of 2-(azaindol-2-yl)benzimidazole, useful as PAD4 inhibitors are obtained. n 10 cl, 30 ex |