| abstract |
FIELD: biochemistry. n SUBSTANCE: described protein which binds to genome factor IX (FIX), polynucleotide coding such protein, recovered host cell expressing the protein and method for protein expression. Presented protein includes genetically engineered DNA-binding domain of protein of "zinc finger" type, where DNA-binding domain contains four or five regions of recognising"zinc finger". n EFFECT: presented inventions can be used in clinical practice in patients with hemophilia B. n 15 cl, 5 dwg, 1 tbl, 5 ex |