| abstract |
FIELD: pharmaceutics. n SUBSTANCE: invention refers to pharmaceutical and cosmetic industry and represents multiple emulsion for application of at least one pharmaceutical or cosmetic active substance, which includes external aqueous phase W 1 , oil phase O, dispersed in external aqueous phase, and inner aqueous phase W 2 dispersed in oil phase O, where in inner aqueous phase W 2 there is at least one electrolyte, selected from group of alkali and alkali-earth metals halides and sulphates, and at least one hydrophilic active substance, where multiple emulsion is characterized by, that external aqueous phase W 1 contains hydrophilic emulsifier, which is ethylene oxide and propylene oxide polymer, oil phase O is formed by triacylglycerols and contains lipophilic emulsifier from dimeticones group, and hydrophilic active substance, which is oligonucleotide having sequence according to SEQ ID No: 1 – SEQ ID No: 148 or SEQ ID No: 150. n EFFECT: invention provides high stability, efficient protection of active substances against external effects and protection against microorganisms damages. n 20 cl, 1 tbl, 3 dwg |