| abstract |
FIELD: medicine. n SUBSTANCE: group of inventions relates to medicine, specifically to immunology, and can be used for preparing an immunogenic composition. Multivalent immunogenic composition contains 13 different polysaccharide-protein conjugates with a physiologically acceptable medium. Each of polysaccharide-protein conjugates contains capsular polysaccharide from separate serotype Streptococcus pneumoniae, conjugated with carrier protein CRM 197 . Capsular polysaccharides are obtained from 12 serotypes, selected from a group consisting of 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, and serotype 2 or 9N. Group of inventions also relates to a pharmaceutical composition for inducing immune response to capsular polysaccharide conjugates Streptococcus pneumoniae. n EFFECT: use of one type of carrier protein conjugated with encapsulated polysaccharides in a multivalent vaccine enables to avoid possible immune interference. n 7 cl, 3 ex |