| abstract |
FIELD: pharmaceutics. n SUBSTANCE: present invention relates to a compound and its pharmaceutically or cosmetically acceptable salts, used as an inhibitor of sodium-dependent glucose co-transporter, antioxidant and for depigmenting the skin in medicine and cosmetology, of the following formula (I): n , n as well as methods of its production and compositions based thereon, where n, m and p are independently 0 or 1, R denotes CH 2 OH or CH 2 OR 11 ,R 1 and R 2 are OH or OR 15 , R 3 is OH or OR 18 , R 4 is a hydrogen atom, when n=1, or a hydrogen atom, a halogen atom or OH group, when n=0; X 1 is a hydrogen atom, halogen atom, OH group, (C 1 -C 6 )-alkyl or OR 24 ; U, V and W denote phenyl, pyrazolyl, N-(C 1 -C 6 )alkyl-pyrazolyl or thienyl optionally substituted by one or more substitutes selected from a halogen atom, OH, (C 1 -C 6 )-alkyl and OR 24 ; R 11 , R 15 and R 18 are aryl-(C 1 -C 6 )-alkyl and R 24 is (C 1 -C 6 )-alkyl or aryl-(C 1 -C 6 )-alkyl. In the proposed methods a compound of formula (II) is fluoridated, or compounds of formulae (VIII) and (XI) n n n n n , n n n n are bound, wherein OH group in position of R 4 in the binding product of formula (I) is optionally substituted by halogen, or the compound of formula (I) is bromated with subsequent reconstruction, or a compound of formula (XVI) is associated with a compound of formula (V), where R, R 1 , R 2 , R 3 , X 1 , U, V, W, n, m and p are given above, A 1 is -Li or -Mg-Hal, Hal is a halogen atom, R 9 is a leaving group. n EFFECT: new agent is disclosed which is suitable for bleaching and depigmentation of skin, as an antioxidant, for inhibition of sodium-dependent glucose co-transporter, such as SGLT1, SGLT2 and SGLT3, and diseases, where such inhibition is effective, in particular in the treatment or prevention of diabetes and diabetes-related complications. n 21 cl, 69 ex, 11 dwg |