| abstract |
FIELD: biotechnology. n SUBSTANCE: invention relates to genetic engineering, particularly, to screening of substances having weight control effect, and can be used in medicine. Method of screening substances having weight control effect, involves bringing test substance into contact with cells expressing Synoviolin gene, and identifying whether above test substance has or not inhibiting effect on Synoviolin gene expression. Pharmaceutical compositions include nucleic acid, which suppresses Synoviolin gene expression, or Synoviolin protein ubiquitinylation activity inhibitor. n EFFECT: invention makes it possible to effect on weight reduction by inhibition of gene expression or Synoviolin protein activity. n 4 cl, 5 dwg, 1 ex |