abstract |
FIELD: biotechnology. n SUBSTANCE: invention relates to biotechnology, specifically to a new HIV immunogens, and can be used in medicine for treating or preventing a disease caused by HIV infection. Polypeptide - version gp120 HIV-1 with SEQ ID NO: 4 is taken by method of fast extraction immunogens (RIS) based on the binding a library of recombinant viruses, containing randomized HIV gp120 variants of a surface polypeptide located on the antibodies with neutralizing activity. n EFFECT: invention enables effectively induce antibodies with neutralizing activity against HIV-1. n 7 cl, 5 dwg, 1 tbl |