| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a piperidine derivative of formula 1, stereoisomers or pharmaceutically acceptable salts thereof. Compounds of formula 1 have GPR119 agonist properties. In formula 1 [formula 1] W is O or N-R h group; R a , R b and R h each independently is H or C 1-3 alkyl group; R c is -F or -C 1-3 hyperfluoride alkyl group; R d and R e are each independently selected from a group consisting of H, halogen, -C 1-5 alkyl group; or R d and R e are combined to form a -C 3-7 cycloalkyl group; selected from a group consisting of: , where Rf 1 and Rf 2 are each independently H, halogen or -CN group; selected from a group consisting of: , where Rk 1 and Rk 2 are each independently H, -CN Group, halogen or -C 1-5 alkyl(OH) group; is ; Q is H, -S(O)R 1 group, -S(O) 2 R 1 group, -C(O)R 1 group, -C(O)OR 1 group, -C(O)NHR 1 group, -C(O)NR 2 R 3 group, -S(O) 2 NHR 1 group, -S(O) 2 NR 2 R 3 group or . Invention also relates to a pharmaceutical composition. n EFFECT: novel piperidine derivatives of formula 1, which control GPR119 activity, are obtained. n 8 cl, 183 tbl, 131 ex |