| abstract |
FIELD: pharmaceutics. n SUBSTANCE: invention relates to pharmaceutics. Modified release pharmaceutical composition is described. Composition contains 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazole-4-yl-ethinyl]-pyridine, speed-controlling polymer, and pH-dependent polymer. speed-controlling polymer is hydroxypropyl cellulose, hydroxypropyl methylcellulose, methylcellulose, ethylcellulose, or microcrystalline cellulose, and pH-dependent polymer is selected from group including ionic poly-(meth)-acrylates. n EFFECT: invention provides preparing dosage forms for sparingly soluble said active substance of modified release for reducing pH influence. n 18 cl, 11 dwg, 7 ex |