| abstract |
FIELD: medicine. n SUBSTANCE: present invention refers to immunology. Disclosed is an isolated peptide, capable of inducing cytotoxic T-lymphocytes (CTL) against NEIL3 protein in presence of antigen-presenting cells (APC), carrying HLA-A*0201 and/or HLA-A*0206. Also described are: an isolated polynucleotide coding disclosed peptide, and a vector for expression of said peptide in a host cell. Furthermore, invention covers application of peptide, APC and exosomes according to invention as an active ingredient in preparing a pharmaceutical composition for treating or preventing tumour; composition for inducing CTL and a pharmaceutical composition for treating or preventing malignant tumours, expressing NEIL3 and/or preventing postoperative recurrence. Presented are APC and an exosome, capable of inducing CTL, methods of inducing APC and CTL, as well as a method of inducing immune response against malignant tumours, expressing NEIL3 in a subject. n EFFECT: present invention can find further application in therapy of diseases characterised by high expression of NEIL3. n 14 cl, 9 dwg, 4 tbl |