http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2600736-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27066f7c908dba5a84baecaa28fc21e1 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D489-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-542 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-485 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D489-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 2010-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce08d1194a8f229e153001677e11adcf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_954d27da071057213d569e0b439cc085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_659eea8fe51a231b2044900393590617 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1c338f3158732e793c33b7820e4a3aa |
| publicationDate | 2016-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2600736-C2 |
| titleOfInvention | Compositions comprising enzyme-cleavable ketone-modified opioid prodrugs and optional inhibitors thereof |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to compounds of formula KC-(II), use thereof in treating or preventing pain, method for production thereof, pharmaceutical compositions based thereon, single dose containing same, method for production thereof, method of identifying a compound of formula KC-(II), method of reducing potential abuse of composition containing a compound of formula KC-(II). In general formula KC-(II), R a is hydrogen or hydroxyl; R 5 is selected from (1-6C)alkyl and (1-6C) alkyl, substituted with (1-6C)alkxoycarbonyl group; each R 1 is independently selected from hydrogen and (1-6C)alkyl; each R 2 is independently selected from hydrogen, (1-6C)alkyl, and-C(O) NR 21 R 22 , where R 21 and R 22 are independently selected from a group consisting of hydrogen, (1-6C)alkyl and (1-6C)alkyl, substituted -C(O)OR 60 , where R 60 is hydrogen; n equals a whole number from 2 to 4; R 3 is hydrogen; R 4 is , where each R 6 is independently selected from hydrogen and (1-6C)alkyl, substituted guanidyl group or an amino group; W is -NR 8 -; R 8 is hydrogen; p equals 1 or 2; and R 7 is selected from acyl and acyl substituted with -COOH or-NHCOCH 3 . n EFFECT: novel pharmaceutical compositions. n 18 cl, 20 dwg, 25 tbl, 41 ex |
| priorityDate | 2009-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 518.