| abstract |
FIELD: pharmaceutics. n SUBSTANCE: invention relates to a compound of formula I or its pharmaceutically acceptable salts thereof. Compound of formula (I) possess the properties of BACE1 and/or BACE2. In formula I: n n n n R 1 represents a 6-member heteroaryl containing 2 heteroatoms selected from N substituted with a substitute C 2-6 -alkynyl-C- 1-6 -alkoxy; R 2 is a halogen atom; R 3 is C 1-6 -alkyl; R 4 is selected from a halogen atom; R 5 is selected from a halogen atom; R 6 is selected from a hydrogen atom, and R 7 is selected from a hydrogen atom. Invention also relates to a tritium labelled compound of formula Ia, 11 C-labelled compound of formula Ia', structural formulae are given in the claim, to a method for diagnostic imaging BACE1 enzyme, use of compounds when preparing the composition for diagnostic imaging BACE1, to a pharmaceutical composition, use of compounds in preparing a drug, to a method of inhibiting activity BACE1 and/or BACE2. n EFFECT: obtaining novel compounds of formula I possessing the properties of BACE1 and/or BACE2. n 33 cl, 7 tbl, 9 ex |