| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to derivatives of 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indole-acetic acid with formula (I) or pharmaceutically acceptable salt of such compound, where R 1 and R 2 represent independently of each other hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy group, halogen, trifluoromethoxy group or trifluoromethyl; R 3 represents hydrogen, (C 1 -C 4 )alkyl, (C 1 -C 2 )alkoxy-(C 2 -C 3 )alkyl, (C 1 -C 4 )fluoroalkyl or (C 3 -C 6 )cycloalkyl-(C 1 -C 2 )alkyl; and R 4 represents heteroaryl group, which is unsubstituted or mono-substituted, where substitutes are independently selected from group comprising halogen, (C 1 -C 4 )alkyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 4 )alkoxy group, (C 1 -C 4 )fluoroalkyl and phenyl; where term "heteroaryl" denotes 5-10-member monocyclic or bicyclic aromatic ring containing one nitrogen atom and optionally one additional heteroatom selected from oxygen, nitrogen and sulphur. Invention also relates to the pharmaceutical composition based on compound with formula (I) and application of compound with formula (I). n EFFECT: obtaining new heterocyclic compounds having antagonistic activity in relation to CRTH 2 receptor. n 17 cl, 19 dwg, 51 ex |