| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a novel compound of formula 32 and to a method of producing a compound of formula XLV using a compound of formula 32 as a starting compound. Compounds of formula XLV can inhibit kinase family of JAK-kinase, in particular JAK2 kinase. Compounds XLV can be used for treating myeloproliferative disease, in treating idiopathic polycytemia, primary thrombocytopenia, myeloid fibrosis, proliferative diabetic retinopathy, cancer or eye disease. Compound of formula 32 corresponds to structural formula n n n n n given below. Method of producing a compound of formula XLV involves reaction of 3-bromo-N-tert-butylbenzosulphonamide with a compound of formula 32. Method involves cleaning reaction mixture obtained at step of reacting a compound of formula 32 with 3-bromo-N-tert-butylbenzosulphonamide for extraction of compound of formula XLV. n EFFECT: obtaining a compound of formula XLV using compound of formula 32 as a starting compound. n 3 cl, 2 dwg, 3 tbl, 246 ex |