| abstract |
FIELD: medicine. n SUBSTANCE: group of inventions relates to medicine and concerns a pharmaceutical microspherical composition containing rotigotine or pharmaceutically acceptable salt thereof; at least one polylactide-glycolide (PLGlA) with molecular weight of 5,000-100,000 Da and polymerisation ratio lactide:glycolide 95:5 to 5:95; and at least one fatty acid having 8-24 carbon atoms, where content of rotigotine or pharmaceutically acceptable salt thereof is 20-40 %, PLGlA is 45-79 %, and at least one fatty acid is 1-15 wt% relative to total weight of composition. Group of inventions also relates a method of treating Parkinson's disease using said compositions. n EFFECT: group of inventions provides rotigotine composition, which significantly reduces explosive release of preparation. n 23 cl, 28 ex, 12 tbl, 38 dwg |