| abstract |
FIELD: medicine. n SUBSTANCE: presented group of inventions relates to non-viral RNA delivery for immunisation. Disclosed is liposome for RNA in vivo delivery into cell of vertebrate animal with lipid bilayer containing lipid, having tertiary amine and value of pKa from 5.0 to 6.8, which encapsulates water core including RNA coding immunogen. Invention also discloses pharmaceutical composition containing said liposome, method of producing liposomes, method of inducing protective immune response in vertebrate animal and application of liposomes or pharmaceutical composition for inducing protective immune response in vertebrate animal. n EFFECT: presented group of inventions provides effective in vivo delivery of RNA for induction of protective immune response in vertebrate animal. n 15 cl, 21 dwg, 18 tbl, 1 ex |