| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to methods of producing chiral compounds, particularly to method of producing chiral compound of formula (II). Method involves reaction of chiral compound of formula (I) with H 2 N-NH-CHO in solvent to obtain compound of formula (II). In formulae (I) and (II) Y denotes substituted or unsubstituted aryl fragment, wherein substituted aryl fragment contains 1, 2 or 3 substitutes, which are selected from group comprising halogen, alkyl and C 1 -C 6 alkoxy group. Invention also relates to methods of producing chiral compounds of formulae (III)-(V) using method of producing chiral compound of formula (II), chiral compounds of formulae (II)-(V) and use thereof to obtain fungicidal agent, preferably of posaconazole. n EFFECT: in formulae (III)-(V) Y has value specified for compounds of formulae (I) and (II); R aa , R bb and R cc can be identical or different and denote alkyl or aryl residue; R 1 denotes an alkyl residue. n 31 cl, 2 dwg, 3 ex |