| abstract |
FIELD: chemistry. n SUBSTANCE: disclosed are compounds and compositions based thereon, used in medicine, of formulae n n n n and n , n a nucleic acid (II), where Y is -(CH 2 ) 3 -; R 1 is -(C1-6)alkyl; or -(CH 2 ) m -phenyl, optionally substituted up to four times with a substitute selected from: -NO 2 , -CN, or a halogen; R 2 is hydrogen; -(CH 2 ) k -phenyl; -(C1-6)alkyl; -(CH 2 ) k -C(O)-NH 2 ; or -(CH 2 ) k -N-C(Ph) 3 . The phenyl rings are optionally substituted with -O-(C1-4)alkyl; R 3 is -NH-phenyl, wherein the phenyl is further substituted with a substitute independently selected from -(CH 2 )-OH or -(CH 2 )-O-C(O)-O-(4-nitrophenyl); k equals 1, 2, 3, 4, 5 or 6; m equals 1, 2, 3 or 4; and n equals 0 or 1, R a is -(CH 2 ) k -NH 2 ; R 1 , wherein the nucleic acid is a single-stranded RNA oligonucleotide. n EFFECT: novel compounds for nucleic acid delivery in cells and compounds for production thereof. n 10 cl, 653 ex, 19 tbl, 6 dwg |