| abstract |
FIELD: medicine, pharmaceutics. n SUBSTANCE: invention refers to organic chemistry, namely to derivative 2-oxo- and 2-thioxodihydroquinoline-3-carboxamides of formula in the form of free compounds, or in the form of salts of physiologically acceptable acids or bases, wherein X means O or S, R 1 represents an unsubstituted C 1-7 -aliphatic residue; or aryl specified in phenyl unsubstituted or monosubstituted by at least one substitute specified in a group, which contains F, Cl, Br; R 2 represents CF 3 ; C 1-4 -aliphatic residue or O-C 1-4 -aliphatic residue, wherein C 1-4 aliphatic residue in each case is unsubstituted; each R 3 , R 4 , R 5 and R 6 independently represents H; F; Cl; Br; CN; CF 3 ; OCF 3 ; provided at least one of R 3 , R 4 , R 5 and R 6 does not represent H; R 7 represents C 1-7 -aliphatic residue unsubstituted, or mono- or disubstituted; or 6-merous heterocycloaliphatic residue specified in tetrahydropyrane; wherein the 'aliphatic residue' in each case can be branched or unbranched, saturated; wherein 'mono- or disubstituted' in relation to the 'aliphatic residue' refers in the view of respective residues or groups, to substitution of one or two hydrogen atoms specified in one or two hydrogen atoms, each independently, by at least one substitute specified in a group, which contains OH, O-C 1-4 -aliphatic residue, COOH or C(=O)-O-C 1-4 -aliphatic residue. The invention also refers to a pharmaceutical composition based on the compound of formula (I). n EFFECT: new compounds effective in treating and/or preventing diseases mediated by KCNQ2/3 K + canals are produced. n 8 cl, 2 tbl, 45 ex |