| abstract |
FIELD: bioengineering. n SUBSTANCE: claimed invention discloses an isolated antibody or its fragment related to human Axl and described by the sequences of hyper variable sections CDR. Besides, it discloses a nucleic acid, a host cell and the production of the antibody or its fragment. Also, it presents an immunoconjugate including the antibody or its fragment and a cytotoxic agent. And, a pharmaceutical composition for aiming at the pathological states related with the expression and/or activity of the signal transmission cascades Axl. The application of the antibody or its fragment is described for the production of preparations for the treatment of malignant growth and for the inhibition of constitutive activation Axl. n EFFECT: application in the therapy of Axl-related diseases. n 18 cl, 12 dwg, 1 tbl |