http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2576232-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_169f6665a591df987418c35272a00cd9 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7cc45802254b87b222ebe9ab0688a996 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a7e8c11a2a97b45b976cb54387644cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8cdd596c296bc3245638a9761a19e12b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4bd7e501fa06465ecc4cffb139344c0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a7c2ebaaac8c7c7853995cac97f1cb3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7416416730cc7b0100cd4f46659a4ca8 |
| publicationDate | 2016-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2576232-C1 |
| titleOfInvention | Recombinant immunotoxin, specific to the cells expressing her2 receptor |
| abstract | FIELD: medicine. n SUBSTANCE: invention refers to immunology, and concerns recombinant immunotoxin specific to cells expressing HER2 receptor. Recombinant immunotoxin comprises guide module in the form of antibody in scFv format, including variable domains of light and heavy chains of monoclonal humanised HER2-specific antibody interconnected by linker, and toxic module as a fragment of pseudomonal A ETA exotoxin. Guide module is presented with antibody 4D5scFv, recombinant immunotoxin comprises flexible hydrophilic hinge-like linker connecting guide module 4D5scFv with toxic ETA module, and KDEL sequence on C-end of the molecule, and recombinant immunotoxin is presented as SEQ ID NO sequence: 2. n EFFECT: using the given recombinant immunotoxin increases toxicity for cells expressing receptor HER2, and, consequently, therapeutic effectiveness. n 4 cl, 6 dwg |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023071987-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2627215-C1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018250360-A1 |
| priorityDate | 2014-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.